Arima Genomics Completes Customer Validation and Launches Arima-HiChIP Kits and Services
Arima Genomics, Inc., a biotechnology company focused on accelerating the adoption of genome structure information toward medical research, diagnosis and therapy, announced today the full commercial launch of the HiChIP application built on its existing Arima-HiC platform. With this launch, researchers can now obtain long-range chromatin interactions specifically enriched at genomic locations occupied by proteins of interest from a single experiment, enabling speed to discovery and publication with reduced costs.
This public launch brings to a close successful market development and beta testing programs that yielded further proof of market need, improved product performance with enhanced quality control, and delivered valuable feedback from customer validations. “We are very pleased with the data obtained with the Arima HiChIP protocol,” said Tamas Ordog, Professor of Physiology at Mayo Clinic. “The results show great reproducibility and excellent overall quality, and the kit saves time and sequencing cost. We particularly value the straightforward quality control steps and the ease of use – overall, Arima HiChIP is of great value.” Key opinion leader Peter Scacheri, Professor at Case Western University and Member of the Case Comprehensive Cancer Center, stated, “We are pleased with the informative nature and quality of the Arima-HiChIP data.”
HiChIP data can inform mechanistic underpinnings of gene regulation and how it eventually leads to a disease state. "Enriching for active chromatin features through H3K27ac or H3K4me4 HiChIP enables our discovery of high-resolution chromatin looping events that facilitate gene control in muscle stem cells during the transition from a state of quiescence to their commitment toward differentiation into regenerating myofibers, during muscle regeneration in healthy conditions, aging or diseases such as muscular dystrophies,” said Lorenzo Puri, Professor, Development, Aging and Regeneration Program at Sanford Burnham Prebys Medical Discovery Institute.
Recognizing the value of HiChIP and in the absence of commercially validated kits, the scientific community had been homebrewing this biochemistry. “We have been homebrewing HiChIP because it provides critical insights that were previously obtained by performing separate HiC and ChIP-Seq experiments,” said Yin Shen, Assistant Professor at University of California, San Francisco, who studies the genetics of Neuropsychiatry. “Arima-HiChIP generated superior data quality and reproducibility even with our most challenging terminally differentiated neuronal samples, where our homebrew version previously failed, thus saving us from substantial repeat costs.”
Feedback and data generated by early customers also helped to understand the positioning of HiChIP in the context of related assays such as HiC and ChIP-Seq. In particular, while HiC reflects the global framework of genome organization, HiChIP enriches for targeted chromatin interactions originating from specific genomic locations of research interest. Depending on the requirements of the study, a researcher can leverage comprehensive HiC, finer resolution HiChIP, or, both. “The combined analysis of this HiChIP data with our genome-wide HiC data is pivotal to our understanding of both the broader compartmentalization and topological frameworks that influence gene regulation, but also the finer resolution connections between specific cis-regulatory elements," added Puri.
Importantly, because the chromatin interaction data from HiChIP reflect the inherent folding (and misfolding) of the genome in three-dimensions, this can also inform aspects of misregulated genes on a rearranged cancer chromosome – critical insights missed from traditional ChIP-Seq experiments. “Not only do we observe intra-chromosomal cis-regulatory interactions across cancer genomes, but also inter-chromosomal ectopic cis-regulatory interactions on rearranged chromosomes. We think this data will help better delineate the relationship between genetic and epigenetic driver events in cancer,” added Scacheri.
In response to customer needs for data analysis, the company collaborated with academic partners to optimize community-validated open-source bioinformatics tools such as MAPS. The Arima MAPS pipeline automatically outputs easily understandable quality control statistics and upon user’s push-button to proceed, it generates chromatin interaction heatmaps and arc plots to be readily visualized in genome browsers. In addition to the streamlined data analyses, the company’s focus to enhance customer service and support experience is part of its sustained efforts to expedite sample-to-discovery and publication. “The Arima Technical Support Team has been outstanding,” added Ordog.
The company has developed HiChIP on its existing Arima-HiC platform to enable both HiC and HiChIP from one universal Arima kit. Additionally, the company has scaled its operations and strengthened its commercial team to make these kits globally accessible. “The launch of our customer-validated Arima-HiChIP kits and services marks a significant milestone, because it enables commercialization of both a targeted HiC approach and also an enhancement to traditional ChIP-Seq,” said Joseph Spidle, Commercial Director at Arima Genomics. “Our goal is to add meaningful and scientifically relevant applications to the Arima-HiC platform as we democratize the availability of genomic structural insights to accelerate basic and disease related research.”
About Arima Genomics
Arima Genomics, Inc. is a biotechnology company that aims to accelerate the understanding of genome sequence and structure and their role in health, disease, and species evolution. For additional information, please visit: http://www.arimagenomics.com.
CEO, Arima Genomics
About Business Wire
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
Nike Extends its Athletic Leadership5.2.2020 19:00:00 CET | Press release
Today, NIKE, Inc. (NYSE: NKE), unveiled breakthrough innovation for athletes competing in the Tokyo 2020 Games, including footwear designed to provide runners with a measurable performance benefit for a new era of competition. The NEXT% platform, introduced by barrier-breaking marathoner Eliud Kipchoge, will now expand into new disciplines following its unparalleled success in distance running. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20200205005708/en/ An international group of athletes joined the Nike 2020 Forum in New York to unveil the brand's latest performance and sustainable innovations. From left to right: Ibtihaj Muhammad, English Gardner, Leticia Bufoni, Blake Leeper, Timothy Cheruiyot, Dina Asher-Smith, Tomoya Ochiai, Sky Brown, Chris Mosier, Nyjah Huston, DeAnna Price, Bebe Vio, Kevin Mayer, Megan Blunk, Brandi Chastain, Aaron Brown, Sophie Hahn, Aori Nishimura, Diana Taurasi, Miles Chamley-Watson, Leon Schae
Cepton Expands With $50 Million Investment From Koito5.2.2020 18:00:00 CET | Press release
Cepton Technologies, Inc., a leading provider of state-of-the-art, intelligent, lidar-based solutions, announced today that it has raised over $50 million in Series C funding. This brings Cepton’s total funding to nearly $100 million, providing a strong foundation to substantially ramp up its R&D efforts, expand its footprint in the automotive market and support major customers worldwide. The latest funding round was led by Koito Manufacturing Co., Ltd. (TYO:7276), the automotive Tier 1 and world-leading provider of automotive lighting systems, with an investment of $50 million. Existing investors in Cepton also participated in this round. As part of the transaction, Koito will obtain non-exclusive rights to manufacture and sell Cepton’s lidar sensor design for an automotive application, using key components supplied by Cepton. Cepton will use the proceeds to accelerate development and deployment of its advanced lidar technology in ADAS applications, in autonomous vehicle applications,
Imricor Announces First Cases Successfully Performed at Heart Center Dresden5.2.2020 17:40:00 CET | Press release
Imricor Medical Systems, Inc. (Company or Imricor) (ASX:IMR) is pleased to announce the first procedures using the Company’s products following CE mark of the Vision-MR Ablation Catheter have been performed at the Heart Center Dresden. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20200205005672/en/ Drs. Christopher Piorkowski (left) and Thomas Gaspar (right) performing iCMR ablations at the Heart Center Dresden (Photo: Heart Center Dresden). Three procedures were successfully performed over two days by Dr. Christopher Piorkowski and Dr. Thomas Gaspar (https://www.herzzentrum-dresden.com/rhythmologie/unser-team/). Additional physicians at the Heart Center Dresden will also begin performing procedures immediately. These procedures mark the first iCMR ablations anywhere in the world to ever be performed outside of a clinical trial. They were performed in an iCMR lab fitted with a Siemens 1.5T MAGNETOM Aera MR scanner. “It’s ano
VALBIOTIS Announces a Global Strategic Partnership With NESTLÉ HEALTH SCIENCE For the Development and Commercialization of TOTUM-63, a Plant-derived Active Substance With Clinically Demonstrated Metabolic Health Benefits on Prediabetics5.2.2020 17:30:00 CET | Press release
Regulatory News: VALBIOTIS (Paris:ALVAL) (FR0013254851 – ALVAL / PEA/SME eligible ), a Research & Development company committed to scientific innovation for preventing and combating metabolic diseases, announces the signature of a global long-term strategic partnership with Nestlé Health Science for the development and commercialization of TOTUM-63, an innovative and patented combination of 5 plant extracts specifically designed to reduce the risk of developing Type 2 Diabetes on prediabetics. Sébastien PELTIER, CEO of VALBIOTIS states: “Nestlé Health Science is an ideal strategic partner for VALBIOTIS. Its global reach, strategic intent to develop science-based nutritional health solutions and focus on fighting metabolic disorders like diabetes will be instrumental to TOTUM-63's worldwide commercialization success. We are excited about the opportunity that this deal brings to VALBIOTIS and to the many millions of people around the world at risk of becoming Type 2 diabetics. This trans
Skilling lanserar branschens första sömlösa integration med Spotwares cTrader, inriktad på erfarna handlare.30.1.2020 08:00:00 CET | Press release
Forex- och CFD-handelsplattformen Skilling annonserade förra veckan lanseringen av branschens första sömlösa integration med Spotwares cTrader - en unik funktion som internt kallas Ett konto. Två plattformar. Detta pressmeddelande använder multimedia. Se den fullständiga versionen här: https://www.businesswire.com/news/home/20200130005070/sv/ Skilling lanserar branschens första sömlösa integration med Spotwares cTrader. (Photo: Business Wire) Funktionen gör att Skilling kan erbjuda sina kunder sömlös handel över två olika handelsplattformar på ett enda Skilling-konto utan att behöva finansiera och hantera två olika konton separat. ”Enkelt uttryckt ville vi ge våra kunder valet vilken handelsplattform de kan använda - vår egen Skilling Trader eller en mer avancerad klientorienterad cTrader. Problemet du har med andra mäklare som erbjuder flera plattformar är behovet av att finansiera två konton separat, upprätthålla sunda marginaler på två olika konton och också ha två uppsättningar av
inRiver utser Per-Olof Schroeder till ny VD29.1.2020 16:43:00 CET | Press release
inRiver, som levererar SaaS-baserade lösningar för Product Information Management (PIM), meddelar att styrelsen idag har utsett Per-Olof Schroeder till ny VD för bolaget. Per-Olof tillträder sin tjänst med omedelbar verkan. “Styrelsen tackar Thor Johnson för hans ledning av bolaget under de två senaste åren, och är glada över att välkomna Per-Olof som vår nye VD," säger inRivers styrelseordförande, Jorgen Smidt. "Per-Olof har en påvisad erfarenhet av att mycket framgångsrikt leda utveckling av SaaS Computing Services, molnbaserade tjänster, och samtidigt leverera stark tillväxt både gällande intäkter, lönsamhet och marknadsandelar. I sin roll som bolagets VD kommer han fortsätta att utveckla inRivers mission att hjälpa våra kunder bli bäst på att marknadsföra och sälja sina produkter." Schroeder har mer än 25 års erfarenhet av ledande befattningar inom IT-branchen, inklusive 15 år på Microsoft, varav sju år som chef över Microsofts Productivity & Business Process Business Group i väste
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.Visit our pressroom