Arima Genomics Completes Customer Validation and Launches Arima-HiChIP Kits and Services
Arima Genomics, Inc., a biotechnology company focused on accelerating the adoption of genome structure information toward medical research, diagnosis and therapy, announced today the full commercial launch of the HiChIP application built on its existing Arima-HiC platform. With this launch, researchers can now obtain long-range chromatin interactions specifically enriched at genomic locations occupied by proteins of interest from a single experiment, enabling speed to discovery and publication with reduced costs.
This public launch brings to a close successful market development and beta testing programs that yielded further proof of market need, improved product performance with enhanced quality control, and delivered valuable feedback from customer validations. “We are very pleased with the data obtained with the Arima HiChIP protocol,” said Tamas Ordog, Professor of Physiology at Mayo Clinic. “The results show great reproducibility and excellent overall quality, and the kit saves time and sequencing cost. We particularly value the straightforward quality control steps and the ease of use – overall, Arima HiChIP is of great value.” Key opinion leader Peter Scacheri, Professor at Case Western University and Member of the Case Comprehensive Cancer Center, stated, “We are pleased with the informative nature and quality of the Arima-HiChIP data.”
HiChIP data can inform mechanistic underpinnings of gene regulation and how it eventually leads to a disease state. "Enriching for active chromatin features through H3K27ac or H3K4me4 HiChIP enables our discovery of high-resolution chromatin looping events that facilitate gene control in muscle stem cells during the transition from a state of quiescence to their commitment toward differentiation into regenerating myofibers, during muscle regeneration in healthy conditions, aging or diseases such as muscular dystrophies,” said Lorenzo Puri, Professor, Development, Aging and Regeneration Program at Sanford Burnham Prebys Medical Discovery Institute.
Recognizing the value of HiChIP and in the absence of commercially validated kits, the scientific community had been homebrewing this biochemistry. “We have been homebrewing HiChIP because it provides critical insights that were previously obtained by performing separate HiC and ChIP-Seq experiments,” said Yin Shen, Assistant Professor at University of California, San Francisco, who studies the genetics of Neuropsychiatry. “Arima-HiChIP generated superior data quality and reproducibility even with our most challenging terminally differentiated neuronal samples, where our homebrew version previously failed, thus saving us from substantial repeat costs.”
Feedback and data generated by early customers also helped to understand the positioning of HiChIP in the context of related assays such as HiC and ChIP-Seq. In particular, while HiC reflects the global framework of genome organization, HiChIP enriches for targeted chromatin interactions originating from specific genomic locations of research interest. Depending on the requirements of the study, a researcher can leverage comprehensive HiC, finer resolution HiChIP, or, both. “The combined analysis of this HiChIP data with our genome-wide HiC data is pivotal to our understanding of both the broader compartmentalization and topological frameworks that influence gene regulation, but also the finer resolution connections between specific cis-regulatory elements," added Puri.
Importantly, because the chromatin interaction data from HiChIP reflect the inherent folding (and misfolding) of the genome in three-dimensions, this can also inform aspects of misregulated genes on a rearranged cancer chromosome – critical insights missed from traditional ChIP-Seq experiments. “Not only do we observe intra-chromosomal cis-regulatory interactions across cancer genomes, but also inter-chromosomal ectopic cis-regulatory interactions on rearranged chromosomes. We think this data will help better delineate the relationship between genetic and epigenetic driver events in cancer,” added Scacheri.
In response to customer needs for data analysis, the company collaborated with academic partners to optimize community-validated open-source bioinformatics tools such as MAPS. The Arima MAPS pipeline automatically outputs easily understandable quality control statistics and upon user’s push-button to proceed, it generates chromatin interaction heatmaps and arc plots to be readily visualized in genome browsers. In addition to the streamlined data analyses, the company’s focus to enhance customer service and support experience is part of its sustained efforts to expedite sample-to-discovery and publication. “The Arima Technical Support Team has been outstanding,” added Ordog.
The company has developed HiChIP on its existing Arima-HiC platform to enable both HiC and HiChIP from one universal Arima kit. Additionally, the company has scaled its operations and strengthened its commercial team to make these kits globally accessible. “The launch of our customer-validated Arima-HiChIP kits and services marks a significant milestone, because it enables commercialization of both a targeted HiC approach and also an enhancement to traditional ChIP-Seq,” said Joseph Spidle, Commercial Director at Arima Genomics. “Our goal is to add meaningful and scientifically relevant applications to the Arima-HiC platform as we democratize the availability of genomic structural insights to accelerate basic and disease related research.”
About Arima Genomics
Arima Genomics, Inc. is a biotechnology company that aims to accelerate the understanding of genome sequence and structure and their role in health, disease, and species evolution. For additional information, please visit: http://www.arimagenomics.com.
CEO, Arima Genomics
About Business Wire
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
Pietro Rosa TBM Signs Multi-year Agreement With Boeing to Supply Titanium Forgings14.7.2020 18:08:00 CEST | Press release
Pietro Rosa TBM is proud to announce that it has signed a long-term agreement with Boeing to supply forgings for use on the 787 Dreamliner, 777X and 737 MAX airplanes. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20200714005848/en/ Left to right: Mauro Fioretti (Pietro Rosa TBM - President & CEO), Antonio De Palmas (Boeing Italy – President) (Photo: Business Wire) The agreement covers a variety of Titanium forgings and represents the first long-term agreement to be placed with Pietro Rosa TBM since the company’s milestone approvals with Boeing in 2018, enhancing Pietro Rosa TBM ability to enact its strategy for the provision of complex forged structural components. The deal with Boeing further reinforces the Pietro Rosa Groups' supply of products in North America. Mauro Fioretti, President and CEO of the Pietro Rosa Group, stated: “This commitment and great trust placed in us by Boeing further underpins our marketplace strat
Kollective Technology to Demonstrate Scalability of Microsoft Teams and Stream Live Events at Microsoft Experience and Technology Centers Worldwide14.7.2020 17:18:00 CEST | Press release
Leading Software-Defined Enterprise Content Delivery Network (SD ECDN) provider Kollective Technology today announced that it was selected by Microsoft Corp. (Nasdaq: MSFT) to demonstrate the scalability of Microsoft Teams for live events at Microsoft Experience and Technology Centers worldwide. Designed to create comprehensive and immersive technology experiences for Microsoft customers looking to adopt innovations that accelerate their Digital Transformation initiatives, Microsoft Experience and Technology Centers highlight the latest in Modern Workplace use cases, including live video broadcasts. By selecting Kollective as the certified ECDN of Experience Centers, Microsoft can now easily showcase how Teams can deliver company-wide, global live events with the help of ECDN technology. Kollective’s ECDN platform, utilizing browser-based peering technology, scales Teams live events without the need to install software or invest in additional network infrastructure. Leveraging the Koll
rf IDEAS wins the HP ® JetAdvantage 2020 Partner Award for Customer Focus14.7.2020 17:00:00 CEST | Press release
rf IDEAS is proud to have received the HP JetAdvantage Partner Award for Customer Focus, presented by HP during its 2020 Partner Conference, held online for participant safety from May 18 to May 22. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20200714005170/en/ HP JetAdvantage Partner Award for Customer Focus (Photo: Business Wire) rf IDEAS is a leading manufacturer of credential readers for logical access and authentication. The HP JetAdvantage Partner Program offers services and resources to help solution providers accelerate development, simplify deployment and streamline integration with HP imaging and printing devices. Through the program, HP and rf IDEAS have worked together for more than 12 years to bring contactless authentication and identification to HP enterprise applications and to HP JetAdvantage Solutions Partners worldwide. One quality that sets rf IDEAS apart is the company’s unwavering commitment to custome
Andersen Global Enters Trinidad and Tobago14.7.2020 15:30:00 CEST | Press release
Andersen Global continues its expansion in the Caribbean by way of a Collaboration Agreement with full-service tax firm Robley Baynes, marking the organization’s debut in Trinidad and Tobago. Established in 2018, the firm provides a full scope of services including tax and advisory, financial, corporate and management. Led by Partners Kendell Robley and Mikhail Baynes, the dynamic and innovative firm assists clients with value-added solutions focused on business improvement and growth, leveraging their resources and experience across a wide range of client engagements. “We constantly strive to provide best-in-class, client-focused solutions with a high-caliber team of professionals,” Kendell and Mikhail said. “Our collaboration with Andersen Global will allow us to expand our capacity and global footprint, bringing opportunities for broader and more seamless service globally.” “We are delighted to work with Kendall, Mikhail and their team in Trinidad and Tobago. Collaborating with Robl
FINEOS Welcomes Allison Morgan as New Senior Sales Executive for North America14.7.2020 15:15:00 CEST | Press release
FINEOS Corporation (ASX:FCL), the leading core platform for life, accident and health insurance globally, today announces the appointment of Allison Morgan as Senior Sales Executive to the FINEOS North American team. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20200714005639/en/ Allison Morgan (Photo: Business Wire) Allison brings nearly 25 years of proven experience as an accomplished absence and disability sales leader and consultant with powerful relationship building, negotiation, communication and presentation skills. She has a proven track record and demonstrated ability to obtain, grow and retain a customer base to support organizational objectives. In her new role at FINEOS, Allison will be responsible for developing new business clients for FINEOS Claims, FINEOS Absence and FINEOS AdminSuite. Alison’s expertise in absence management is especially important as Integrated Disability and Absence management (IDAM) beco
Goodville Mutual Casualty Company Selects DXC Technology to Optimize Claims Operations14.7.2020 15:00:00 CEST | Press release
Goodville Mutual Casualty Company, a leading provider of comprehensive property and casualty insurance products, has chosen DXC Assure Claims from DXC Technology (NYSE: DXC) to optimize Goodville’s claims operations and improve agent and customer experiences. To support Goodville Mutual, DXC Assure Claims will be deployed on Amazon Web Services (AWS) and is designed to deliver: Streamlined claims operations through process automation Digitally enabled end user experiences Intuitive platform configuration that minimizes the need for IT involvement Together, these capabilities and features help reduce costs, stabilize premiums, increase business agility and simplify the claims process for all stakeholders. “After evaluating the market-leading alternatives, we chose DXC Assure Claims because of its modular approach, richness of functionality and overall cost of ownership,” said David Gautsche, president of Goodville Mutual Casualty Company. “DXC’s digital capabilities and industry knowled
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.Visit our pressroom