Business Wire

COVID-19 Vaccine Adjuvant Potentials of Nichi Glucan Dietary Supplement From Japan

Share

ß- glucan produced by AFO-202 strain of black yeast Aureobasidium Pullulans (Nichi Glucan), having immune enhancement potentials through all major pathways, has been recommended worth clinical studies for validation as a vaccine adjuvant in COVID-19 (https://doi.org/10.1080/21645515.2021.1880210). Pathogens entering through nasal or oral route are tackled by mucosal immunity and antibodies in saliva and once inside the body by innate and adaptive immune systems and the trained immunity (TRIM). Nichi Glucan may have beneficial effects through all the above, describes the scientific publication journal associated with the International Society of Vaccines.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20210303005365/en/

Nichi Glucan is reported to have potentials to act through all the four pathways of immune system viz., Mucosal immunity, Adaptive immunity, Innate immunity and Trained immunity. Research on novel beta-glucans is essential to help find ways to boost human immunity, keeping in mind the present Covid-19, mutating variants and future pandemics. (Graphic: Business Wire)

Nichi Glucan is reported to have potentials to act through all the four pathways of immune system viz., Mucosal immunity, Adaptive immunity, Innate immunity and Trained immunity. Research on novel beta-glucans is essential to help find ways to boost human immunity, keeping in mind the present Covid-19, mutating variants and future pandemics. (Graphic: Business Wire)

Nichi Glucan as vaccine adjuvant: Adjuvants are agents that supplement vaccines by enhancing or stabilizing them. Nichi glucan with immunomodulating potential is considered more advantageous as it’s vaccine adjuvant efficacy against Avian influenza (H5N1, H5N2) have been reported (https://pubmed.ncbi.nlm.nih.gov/21532325/), has a safety track record of consumption as a food supplement in Japan since 1996 and beneficial effects in general health documented in human studies described below.

  • Immune enhancement and balancing benefits in studies in cancer patients, young adults and elderly healthy volunteers (https://doi.org/10.3389/fimmu.2020.01548)
  • Coagulopathy related to COVID-19, could be tackled in populations at high-risk for blood clotting disorders; Thrombosis (https://doi.org/10.1186/s12959-020-00239-6)
  • Balancing of blood sugar and cholesterol potential may reduce mortality in SARS-CoV-2 patients; Journal of Diabetes & Metabolic Disorders (https://doi.org/10.1007/s40200-020-00664-4).
  • Beta glucans in Trained immunity is reported to be more robust as they act on bone marrow which produces blood components and immune cells.

Earlier, associates of GN Corporation were granted a patent on Influenza Neutralizing Antibody to identify vulnerable population for vaccine administration, accomplished in collaboration with Dr. Yoshikazu Kurosawa, a monoclonal antibody researcher, recognized by Prof. Susumu Tonegawa in his Nobel prize for medicine – lecture in 1987 (https://www.nobelprize.org/uploads/2018/06/tonegawa-lecture.pdf).

Human beings lack an ability to advantageously mutate their DNA or RNA unlike viruses; therefore, left with the only option of boosting their immune system for protection from evolving new pathogens and mutating viruses. Fungi having contributed significantly to human health yielding antimicrobial agents such as Penicillin and many anti-cancer agents, further research on this black yeast looks very promising said Dr. Gene Kurosawa, a co-author. Clinical studies on prebiotic potentials of Nichi Glucan to solve gut dysbiosis by balancing gut microbiota are underway.

Contact information

Samuel JK Abraham
info@gncorporation.com

About Business Wire

Business Wire
Business Wire



Subscribe to releases from Business Wire

Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.

Latest releases from Business Wire

LEO Pharma Receives Positive CHMP Opinion of Adtralza ® (tralokinumab) for the Treatment of Adults With Moderate-to-Severe Atopic Dermatitis23.4.2021 13:59:00 CEST | Press release

LEO Pharma A/S, a global leader in medical dermatology, today announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has adopted a positive opinion and recommended granting a marketing authorization of Adtralza® (tralokinumab) for the treatment of moderate-to-severe atopic dermatitis in adult patients who are candidates for systemic therapy. The CHMP positive opinion is one of the final steps before the European Commission makes its decision on the Marketing Authorization Application for use of Adtralza, an investigational therapy in clinical development, throughout the European Union. This final decision is expected in the coming months and if authorized, Adtralza will be the first fully human, monoclonal antibody available to specifically target the IL-13 cytokine, a key driver of atopic dermatitis signs and symptoms. Adtralza specifically targets IL-13 with high affinity and is developed to improve the symptoms of atopic derma

Schlumberger Announces First-Quarter 2021 Results23.4.2021 12:50:00 CEST | Press release

Schlumberger Limited (NYSE: SLB) today reported results for the first-quarter 2021. First-Quarter Results(Stated in millions, except per share amounts)Three Months EndedChange Mar. 31, 2021 Dec. 31, 2020 Mar. 31, 2020 SequentialYear-on-yearRevenue* $5,223 $5,532 $7,455 -6% -30% Income (loss) before taxes - GAAP basis $386 $471 $(8,089) -18% n/m Net income (loss) - GAAP basis $299 $374 $(7,376) -20% n/m Diluted EPS (loss per share) - GAAP basis $0.21 $0.27 $(5.32) -22% n/m Adjusted EBITDA** $1,049 $1,112 $1,347 -6% -22% Adjusted EBITDA margin** 20.1% 20.1% 18.1% 0 bps 203 bps Pretax segment operating income** $664 $654 $776 1% -14% Pretax segment operating margin** 12.7% 11.8% 10.4% 88 bps 230 bps Net income, excluding charges & credits** $299 $309 $351 -3% -15% Diluted EPS, excluding charges & credits** $0.21 $0.22 $0.25 -5% -16% Revenue by Geography International $4,211 $4,343 $5,225 -3% -19% North America* 972 1,167 2,180 -17% -55% Other 40 22 50 n/m n/m $5,223 $5,532 $7,455 -6% -30%

ANAORI kakugama: The New Cooking Tool Shaking Up the Culinary World23.4.2021 12:30:00 CEST | Press release

Japanese brand ANAORI, a leader in manufacturing carbon graphite products, has developed a groundbreaking cooking tool that combines new technologies and natural materials in a unique design. In the coming weeks, renowned chefs from around the world will apply their expertise to showcase the potential of ANAORI kakugama. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20210423005016/en/ ANAORI kakugama Watch the ANAORI kakugama video here ANAORI kakugama: The Culinary Tool Combining Tradition and Innovation The philosophy of ANAORI was born out of respect for Japanese culture, rooted in a tradition of living in harmony with nature. Naturality according to ANAORI means understanding the principles of nature without confronting it, multiplying its powers by means of minimal intervention, in order to best utilise it. The Japanese company unveils two ANAORI kakugama models in two different sizes, to cook with the rhythm of the seas

Hiab and FSP enter into agreement on the transfer of surface treatment functions in Poland23.4.2021 11:01:00 CEST | Press release

Hiab, part of Cargotec, and FSP Finnish Steel Painting Ltd have reached an agreement about the surface treatment operations in Hiab’s Stargard multi-assembly unit in Poland as of April 2021. Following the partnership FSP will provide Hiab Poland the surface treatment services and the expertise in development techniques. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20210423005017/en/ Hiab, part of Cargotec, and FSP Finnish Steel Painting Ltd have reached an agreement about the surface treatment operations in Hiab’s Stargard multi-assembly unit in Poland. (Photo: Business Wire) The surface treatment operation in Hiab’s Stargard multi-assembly unit and its associated professionals will transfer to FSP under their current employment conditions. The purpose of the agreement is to intensify the cooperation between Hiab and FSP so that the parties can focus on their own core competencies and improve business development. For severa

JAB Welcomes Lubomira Rochet as Partner23.4.2021 09:30:00 CEST | Press release

JAB is pleased to welcome Lubomira Rochet to the JAB Partnership, effective June 1, 2021. Based in London, Ms. Rochet is a recognized digital leader and business transformer with extensive global experience across multiple industries. She joins JAB following seven years at L'Oréal, where she served as Chief Digital Officer and a member of the Executive Committee. While at L’Oreal, Ms. Rochet successfully led the beauty giant’s marketing and commercial pivot to a digital-first company, scaling E-commerce to 27% of the Group’s revenue with more than 45% average yearly growth during her tenure and accelerating Direct-to-Consumer engagement and reinventing marketing in the digital age. She was recognized as the 2019 Global Marketer of the Year by the World Federation of Advertisers. Ms. Rochet will build on her successful track record of large-scale global business transformations to drive growth and digital leadership in JAB’s portfolio companies. Ms. Rochet will join the Boards of severa

XPRIZE and Musk Foundation Announce Guidelines and Open Registration for $100M XPRIZE Carbon Removal23.4.2021 01:23:00 CEST | Press release

XPRIZE, the global leader in designing and implementing innovative competition models to solve the world’s grand challenges, today announced the official launch of $100 Million XPRIZE Carbon Removal with the opening of team registration and the release of the competition guidelines. The announcement comes shortly after Peter H. Diamandis,XPRIZE founder and executive chairman, and Elon Musk sat down for a live stream hosted on Twitter to discuss the importance of spurring carbon removal solutions, the climate crisis, and the launch of the largest incentive prize in history. The conversation was followed by a virtual question and answer hosted by Marcius Extavour, vice president of climate and environment at XPRIZE, and XPRIZE’s chief impact officer, Zenia Tata. Funded by the Musk Foundation, $100M XPRIZE Carbon Removal is aimed at tackling climate change by asking global innovators to develop solutions that can pull carbon dioxide directly from the atmosphere or oceans and lock it away

Verimatrix To Participate in SportsPro Live Virtual Panel: How To Transform Physical Spaces into Digital Ecosystems22.4.2021 17:45:00 CEST | Press release

Regulatory News: Verimatrix, (Paris:VMX) (Euronext Paris: VMX), the leader in powering the modern connected world with people-centered security, today announced that Lu Bolden, Chief Revenue Officer, is slated to participate in a SportsPro Live virtual panel discussion from 9:10 to 9:55 a.m. Central Time on Thursday, April 29. The event, which unites sports and technology professionals from across the globe, aims to prepare the industries for the future of sport. Bolden’s panel is slated to take place in the South Stand and discuss how technology can connect the in-venue experience to create more revenue opportunities. The group, moderated by Mike Bohndiek, CEO of PTI Digital Group, will also discuss what strategies and technologies can best deliver the new digital experiences. Other speakers on the panel include: Michael Cole, Chief Technology Officer, PGA European Tour and Ryder Cup Europe Adam Heintz, Senior Vice President, Business Intelligence, Monumental Sports & Entertainment “T

In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.

Visit our pressroom