NASDAQ OMX

Karolinska Development's portfolio company Modus Therapeutics announces publication of Phase I/II data demonstrating anti-adhesive properties of sevuparin

Dela

STOCKHOLM, December 20, 2017. Karolinska Development announced today that data from a Phase I/II study of sevuparin in malaria patients was published in an on-line version of the renowned scientific journal PLOS ONE. The paper demonstrates the anti-adhesive properties of sevuparin in patients with malaria. Karolinska Development's portfolio company Modus Therapeutics is currently conducting a Phase II study with sevuparin in patients with sickle cell disease, with an estimated read out in 2018.

Sevuparin is a drug candidate currently being developed for the treatment of sickle cell disease (SCD) and the paper published in PLOS ONE provides the first clinical evidence of anti-adhesive action of sevuparin. SCD is caused by a mutation in the hemoglobin gene which leads to the red blood cells becoming sickled in shape and sticky, attaching to other blood cells and to blood vessels walls. This leads to reduced blood flow and impaired transport of oxygen to vital organs.

The Phase I/II trial was a randomized, open label, active control, parallel assignment clinical study in which sevuparin was administered via short intravenous infusions to patients with uncomplicated malaria who were also receiving atovaquone/proguanil treatment.

Amongst the key findings of the study, which were highlighted in the PLOS ONE publication, were:

  • Sevuparin was safe and well tolerated in malaria patients
  • Sevuparin, due to its anti-adhesive properties, was able to open up previously clogged blood vessels
  • Sevuparin rapidly inhibited the growth of the Plasmodium falciparum, the parasite that causes malaria

This is the first time that these results have been achieved in humans.

The paper titled, "Inhibition of merozoite invasion and transient de-sequestration by sevuparin in humans with Plasmodium falciparum malaria," can be found here:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0188754

For further information, please contact :

Viktor Drvota, CEO, Karolinska Development AB
Phone: +46 73 982 52 02, e-mail: viktor.drvota@karolinskadevelopment.com

TO THE EDITORS

About Karolinska Development AB
Karolinska Development AB (Nasdaq Stockholm: KDEV) is a Nordic life sciences investment company. The company focuses on identifying breakthrough medical innovations in the Nordic region that are developed by entrepreneurs and leadership teams. The Company invests in the creation and growth of companies that advance these assets into commercial products that are designed to make a difference to patients' lives while providing an attractive return on investment to shareholders.

Karolinska Development has access to world-class medical innovations at the Karolinska Institutet and other leading universities and research institutes in the Nordic region. The Company aims to build companies around scientists who are leaders in their fields, supported by experienced management teams and advisers, and co-funded by specialist international investors, to provide the greatest chance of success.

Karolinska Development has established a portfolio of nine companies targeting opportunities in innovative treatment for life-threatening or serious debilitating diseases.

The Company is led by an entrepreneurial team of investment professionals with a proven track record as company builders and with access to a strong global network.

For more information, please visit www.karolinskadevelopment.com




This announcement is distributed by Nasdaq Corporate Solutions on behalf of Nasdaq Corporate Solutions clients.
The issuer of this announcement warrants that they are solely responsible for the content, accuracy and originality of the information contained therein.
Source: Karolinska Development AB (publ) via Globenewswire

Om

NASDAQ OMX
NASDAQ OMX



Följ NASDAQ OMX

Abonnera på våra pressmeddelanden.

Senaste pressmeddelandena från NASDAQ OMX

Notice of Arbitration Filed Against State of Kuwait16.7.2018 21:46Pressmeddelande

Attorneys for international business executive file notice of arbitration claiming violation ofinternational law by Kuwaiti courts London, United Kingdom, July 16, 2018 (GLOBE NEWSWIRE) -- Crowell & Moring LLP, counsel for Marsha Lazareva, a prominent member of the international business community, has filed a notice of international arbitration with the State of Kuwait for breaching a bilateral investment treaty in violation of international law. The notice follows a series of erroneous charges against Lazareva by the Kuwait Prosecutor General that have resulted in her prolonged imprisonment. The notice states that the charges against Ms. Lazareva, a Russian citizen, are part of a coordinated campaign to damage her reputation as a successful businesswoman and diminish the value of her investments. It also cites Kuwait for violating a longstanding bilateral investment treaty with Russia: the Agreement between the Russian Federation and the State of Kuwait on the Encouragement and Mutua

Two London ex-Bankers launch first UK regulated Digital Asset Trading Platform and Crypto exchange accessible to Institutional Investors16.7.2018 17:37Pressmeddelande

LONDON, July 16, 2018 (GLOBE NEWSWIRE) -- UK's first native crypto exchange platform is on its way to become a reality. Sovren Exchange, a venture founded by a team of London-based banking executives, has announced an Initial Coin Offering (ICO) to begin Q3 of this year. For their launch, Sovren (SVRN) is raising a maximum of 10 Million USD (combination of Equity Funding and its own Sovren Token) to create a hybrid order book and brokerage exchange platform that uses a trading engine supported by Artificial Intelligence (AI) and Robotic Process Automation (RPA). Sovren will have a fully compliant platform that will support trading in derivates, equities, commodities and securities. The platform will use intelligent automation to address liquidity challenges and a 3rd party custodial service for additional protection with a European Bank. Sovren is supporting trading between all major crypto assets and fiat currencies like pounds, euros, and dollars, aiming for same day service and low,

TANTALEX Announces Entering into An Agreement with Respect to the Acquisition of an Exploitation Permit for the Historical Manono-Kitotolo Mine Tailings16.7.2018 16:48Pressmeddelande

TORONTO and MUNICH, Germany, July 16, 2018 (GLOBE NEWSWIRE) -- TANTALEX Resources Corporation (CSE:TTX) (FSE:1T0) ("TANTALEX" or the "Corporation"), is pleased to announce that its 90% owned subsidiary Buckell SAS ("Buckell") has entered into an assignment agreement (the "Agreement") to acquire Mines d'Or Resources ("Minor") 65% participation in a joint venture entity to which will be transferred the PER 13698 (Permis Exploitation Rejets) ("PER 13698"). PER 13698 grants exclusive rights to mine the tailings of the historical Manono-Kitotolo mine for lithium, tin and tantalum. The new entity will be named Société des Tailings de Manono ("STM") and will be owned 65% by Buckell, 30% by La Congolaise D'Exploitation Minière ("La Cominière") and 5% by Minor. The closing of the contemplated transaction by Buckell is subject to various conditions and payments, namely, but not limited to, the successful transfer and registration of the PER 13698 in the name of the newly created entity STM with

2018 Farnborough Air Show Marks Debut of Bombardier New ATMOSPHÈRE Cabin16.7.2018 12:00Pressmeddelande

MONTRÉAL, July 16, 2018 (GLOBE NEWSWIRE) -- Bombardier Commercial Aircraft unveiled the interior of the first CRJ Series aircraft with the new ATMOSPHÈRE cabin design on the opening day of the Farnborough International Air Show in the United Kingdom. Bombardier showcased the new cabin alongside launch operator Delta Air Lines and supplier Zodiac Aerospace during its air show inauguration event. "Our product is evolving, and this signature cabin design represents the latest innovation to our very successful regional jet program," said Fred Cromer, President, Bombardier Commercial Aircraft. "This cabin design will add value to airlines, the feedback has already been very positive as demonstrated with the recent momentum we have gained in the market." The CRJ900 aircraft on static display at the airshow is painted in Delta Air Lines livery and fitted with the ATMOSPHÈRE cabin. Bombardier will also emphasize its presence at the airshow from July 16-20 with a display of a Q400 aircraft in t

Fortuna reports production of 2.3 million ounces of silver and 14,557 ounces of gold for the second quarter of 201816.7.2018 11:00Pressmeddelande

VANCOUVER, British Columbia, July 16, 2018 (GLOBE NEWSWIRE) -- Fortuna Silver Mines Inc. (NYSE:FSM) (TSX:FVI) is pleased to report production results for the second quarter of 2018 from its two operating mines in Latin America, the San Jose Mine in Mexico and the Caylloma Mine in Peru. The Company produced 2.3 million ounces of silver and 14,557 ounces of gold plus base metal by-products. Silver and gold production for the first six months totaled 4.7 million ounces and 29,597 ounces respectively; being 13 percent and 20 percent above the Company's mid-year projection. Fortuna is on schedule to produce 8.3 million ounces of silver and 48.3 thousand ounces of gold or 11.4 million Ag Eq1 ounces in 2018 in accordance with our production guidance (see Fortuna news release dated January 17, 2018). Second Quarter Production Highlights Silver production of 2,321,315 ounces; 10 percent increase over Q2 2017 Gold production of 14,557 ounces; in line with Q2 2017 Lead production of 7,186,541 pou

YouGov poll reveals UK adults are seeking innovative, digital payment experiences from their banks16.7.2018 01:04Pressmeddelande

New research showcases a list of innovative ways we'd like better protection against fraud and a more active role in controlling our payment cards· Switching cards on and off for better fraud controls, quickly reactivating blocked cards and mobile app based self-service is the future London, UK, July 16, 2018 (GLOBE NEWSWIRE) -- UK adults are ready for real-time interaction with their banks. The results of a recent YouGov survey, on behalf of Ondot, revealed today that online security and fraud prevention comes top in what Brits think banks should guarantee, with 60% wanting 'peace of mind' when using cards online. The survey also discovered that consumers are keen to play a much more proactive role in managing their personal finances. New ways of managing their card services before, during and after a payment; how, when and where cards are used and the ability switch your card 'on' and 'off' to create extra vigilance against fraud - are all important to today's card user. The omnibus

I vårt pressrum kan du läsa de senaste pressmeddelandena, få tillgång till pressmaterial och hitta kontaktinformation.

Besök vårt pressrum