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Karolinska Developments portföljbolag Umecrine Cognition presenterar positiva fas 1b-data för sin läkemedelskandidat mot hepatisk encefalopati

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STOCKHOLM den 13 september 2017. Karolinska Developments portföljbolag Umecrine Cognition presenterar idag positiva fas 1b-data för sin läkemedelskandidat GR3027, vilken utvecklas för behandling av hepatisk encefalopati.

Hepatisk encefalopati (HE) är ett allvarligt tillstånd som bland annat kan uppträda till följd av skrumplever eller gulsot. Umecrine Cognition är såvitt känt det enda företag som har en läkemedelskandidat i utveckling för att minska risken för medvetandestörningar och andra allvarliga CNS-relaterade symtom i samband med HE.

Resultaten av den nu genomförda fas 1b-studien visar att GR3027 tolereras väl, inte ger upphov till några dosbegränsande biverkningar och att den farmakokinetiska profilen är mycket gynnsam. Den placebokontrollerade studien utfördes på 18 friska individer, där de som behandlades med GR3027 erhöll stigande doser från 50 mg en gång per dag till 100 mg två gånger per dag under en period av fem dagar.

"Vi är entusiastiska över de positiva resultaten i fas 1b-studien med GR3027 och ser nu fram emot att Umecrine Cognition tar läkemedelskandidaten vidare in i fas 2a. Resultaten från denna nästkommande studie förväntas kunna presenteras redan under 2018", säger Viktor Drvota, vd, Karolinska Development.

GR3027 har i tidigare försök ("allopregnanolone challenge study") - redan i doser om 3 mg och 30 mg - visat sig kunna penetrera blodhjärnbarriären och påverka de kroppsegna CNS-aktiva GABA-steroider som orsakar symtom vid bland annat hepatisk encefalopati.

Umecrine Cognitions pressmeddelande med anledning av fas 1b-resultaten finns tillgänglig via följande länk. https://www.umecrinecognition.com/press  

För ytterligare information, vänligen kontakta :

Viktor Drvota, VD, Karolinska Development AB
Tel: +46 73 982 52 02, e-mail: viktor.drvota@karolinskadevelopment.com

Christian Tange, finansdirektör, Karolinska Development AB
Tel: +46 73 712 14 30, e-mail: christian.tange@karolinskadevelopment.com

TILL REDAKTÖRERNA

Om Karolinska Development AB
Karolinska Development AB (Nasdaq Stockholm: KDEV) är ett nordiskt investmentbolag inom life science. Bolaget fokuserar på att identifiera medicinska innovationer och att investera för att skapa och utveckla bolag som vidareutvecklar sådana innovationer till differentierade produkter som kan göra skillnad för patienters liv och generera en attraktiv avkastning till aktieägarna.

Karolinska Development har tillgång till medicinsk forskning i världsklass från Karolinska Institutet och andra ledande universitet och forskningsinstitutioner i Norden. Bolagets målsättning är att bygga bolag kring forskare som är ledande inom sina respektive vetenskapsområden, med stöd från erfarna ledningsgrupper och rådgivare, samt med finansiering tillsammans med internationella investerare som är specialiserade inom sektorn, För att skapa bästa möjligheter till framgång byggs företagen med erfarna managementteam och rådgivare och de medfinansieras av professionella life science-investerare.

Karolinska Developments portfölj består av nio bolag inriktade på att utveckla innovativa behandlingsmetoder för sjukdomar som är livshotande eller funktionsnedsättande och andra medicinska tillstånd.  

Bolaget leds av ett entreprenörsteam bestående av professionella investerare med lång erfarenhet inom företagsbyggande och med tillgång till ett starkt globalt nätverk.

För mer information: www.karolinskadevelopment.com.

Denna information är sådan information som Karolinska Development AB (publ) (Nasdaq Stockholm: KDEV) är skyldigt att offentliggöra enligt EU:s marknadsmissbruksförordning. Informationen lämnades genom Viktor Drvota för offentliggörande den 13 september klockan 08:00.


This announcement is distributed by Nasdaq Corporate Solutions on behalf of Nasdaq Corporate Solutions clients.
The issuer of this announcement warrants that they are solely responsible for the content, accuracy and originality of the information contained therein.
Source: Karolinska Development AB (publ) via Globenewswire

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