Business Wire

Landmark Study Reveals New Technology from DeBogy Molecular Significantly Reduces the Bacteria and Deadly Infection that Can Occur Following a Surgical Implant

Share

DeBogy Molecular, Inc, a biotech startup that specializes in antimicrobial surface modification, today announced the findings of a landmark in vivo research study that affirms the effectiveness and safety of their new technology to kill the dangerous bacteria that proliferates on the surface of a medical implant following surgery.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20220626005067/en/

To view this piece of content from mms.businesswire.com, please give your consent at the top of this page.

Wayne Gattinella CEO, DeBogy Molecular, Inc (Photo: Business Wire)

Infection resulting from bacterial biofilm that forms on the surface of a medical implant represents one of the most serious complications that can follow orthopedic surgery or the implantation of a medical device. Implant related infections account for over half of the 2 million yearly healthcare-associated infections in the U.S., at a cost of over $27 billion dollars annually.

A preclinical research study was conducted by Vivexia, an independent Clinical Research Organization, to evaluate the efficacy and safety of DeBogy-treated titanium implants against the formation of bacterial biofilm. A total of 121 mice were implanted and studied for bacterial attachment on the implant and the level of infection in the surrounding tissue vs untreated control. The study was overseen by a group of medical research scientists and all lab protocols were validated by a veterinary ethics committee.

Study Results Summary

  • Bacterial biofilm on the DeBogy-treated implants wasreduced by 99.97% vs untreated control, 7 days following surgery
  • Bacterial load in the surrounding tissue in animals with DeBogy-treated implants was reduced by 99.8% vs untreated control, 7 days following surgery
  • The surrounding tissue in animals with DeBogy-treated implants was healthier overall, with decreases in inflammation, fibrosis, vascularization, and necrosis
  • Excellent clinical health and biocompatibility were recorded in animals with DeBogy-treated implants

The promise of a new, disruptive technology that can permanently protect the surface of an implantable device from the formation of dangerous bacterial biofilm, without the use of toxic chemicals, coatings or even antibiotics, is truly transformational,” said Wayne Gattinella, CEO of DeBogy Molecular. “The study results affirm that DeBogy technology has the potential to save lives and dramatically improve the quality of life for millions of people, young and old.”

It should be noted that these study results were delivered under a stringent model using a high inoculum of methicillin-resistant Staphylococcus aureus (MRSA) with direct injection into the operative site after skin closure and without the use of antibiotics. This far surpasses most real-world situations for clinical surgical contamination.

“The bacterial reductions reported on the DeBogy-treated implants and in the surrounding tissues vastly outperformed existing scientific literature on similar animal models using conventional treatment,” said Dr Houssam Bouloussa, spine surgeon and cofounder, DeBogy Molecular. This technology has the potential to revolutionize the way we prevent and treat surgical-site infections.”

Initial feedback was collected from key opinion leaders in orthopaedic surgery and infectious disease on the significance of these study findings:

“Implant-related infections are difficult to treat and are often devastating to patients and healthcare payers alike. The results of the DeBogy antimicrobial study bring hope to clinicians like me that an effective preventative measure for implant-related infections is finally on the horizon.”

Dr Matthew Grant,Assistant Professor of Infectious Disease, Yale School of Medicine

“DeBogy technology has the potential to deliver the most important antimicrobial solution to the medical marketplace that I have seen in my 30 years of practice. The efficacy and safety of this new technology can dramatically reduce the patient burden associated with implant related infections.”

Dr James J. Yue, Orthopedic Spine Surgeon, CT Orthopaedic Specialists,
Associate Professor, Frank H Netter School of Medicine,
former Co-Chief of Orthopedic Spine Surgery, Yale School of Medicine

“Periprosthetic joint infections are recognized as a leading cause of morbidity and mortality in orthopaedic surgery. The results of the DeBogy in vivo study show unique promise to introduce a new solution to this recognized postoperative complication.”

Dr Antonia Chen, Orthopedic Surgeon

The complete DeBogy research study will be presented at the North American Spine Society Annual Meeting in Chicago in October 2022. For a copy of the research White Paper send your request to contact@debogy.com.

About DeBogy Molecular

DeBogy Molecular Inc is a biotechnology company dedicated to surface modification innovation. Founded in 2019 after more than 15 years of research and development, our proprietary IP can modify molecular surface structures to electrostatically destroy virus, bacteria, and fungus on contact. The DeBogy platform is effective across a wide range of materials for industries that include medical, consumer health, textiles and industrial manufacturing. Our goal is to ensure a safe, secure, germ-free environment. For more information contact www.debogy.com

About VIVEXIA

Established in 2009, VIVEXIA is a research organization focused on life sciences and health, with headquarters in Dijon, France. VIVEXIA provides a long-standing expertise in preclinical bacterial infections and in the evaluation of innovative lifesaving antibacterials or biocidal medical devices. Through a wide range of reliable models, VIVEXIA supports research initiatives to address the challenge of antimicrobial resistance and biofilm associated/healthcare-acquired infections. For more information contact www.vivexia.fr

To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.

Contact information

Damon Campolo
DeBogy Molecular, Inc
415-310-6299
damon@debogy.com

About Business Wire

Business Wire
Business Wire



Subscribe to releases from Business Wire

Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.

Latest releases from Business Wire

NetWitness Announces New Threat Detection and Intelligence Capabilities with NetWitness Platform XDR 1210.8.2022 20:00:00 CEST | Press release

NetWitness, a globally trusted provider of cybersecurity technologies and incident response, today announced the upcoming availability of NetWitness Platform XDR 12 later this month, the industry’s most comprehensive extended detection and response solution. NetWitness Platform XDR 12 is the first solution on the market to deliver on the promise of extended detection and response. Developed in response to real-world customer needs, NetWitness Platform XDR 12 is focused on sophisticated detection, which is at the core of effective threat defense. The updated platform offers full visibility into all key data planes across an organization including network, logs, endpoint, and Internet of Things (IoT); full Security Orchestration, Automation, and Response (SOAR); a complete Threat Intelligence Platform (TIP); User and Entity Behavior Analytics (UEBA); and new asset analytics and prioritization, all easily viewed in a single interface and a unified data model. “Effective security teams nee

NetWitness Appoints Industry Veteran Ken Naumann as New CEO10.8.2022 18:00:00 CEST | Press release

NetWitness, an RSA® Group Business and globally trusted provider of cybersecurity technologies and incident response services, today welcomes Ken Naumann as the new Chief Executive Officer. “NetWitness has long prided itself on forging the frontier of extended detection and response capabilities, which is becoming increasingly universal amid an industry renaissance that prioritizes investment in threat detection,” said Rohit Ghai, CEO of RSA Group. “With decades of experience in enterprise tech and cybersecurity, Ken brings the right mix of growth, strategy and diligence to take NetWitness to the next level.” Naumann joins NetWitness from AccessData, a provider of digital forensic investigation technology where he led the company’s growth as CEO. Under his leadership and direction, AccessData was one of the world leaders in data forensics before it was ultimately acquired by Exterro. Over his 25-year career, Naumann has served as CEO of a mix of public, private-equity, and venture-back

Coinfirm is Setting the Crypto AML Compliance Standard10.8.2022 17:20:00 CEST | Press release

RegTech heavyweight Coinfirm – in its award-winning AML Platform – has introduced support for cross-blockchain risk analysis, in addition to rolling out Entity Due Diligence (Entity DD). Cross-blockchain analysis gives crypto compliance monitoring teams unprecedented levels of insight in contexts where a crypto address was involved in a transaction crossing between different blockchains. Entity DD, on the other hand, provides detailed information about entities operating in the blockchain ecosystem. Cross-blockchain analysis takes into account incoming and outgoing transactions on the monitored bridges, asset types, block heights, timestamps and other on-chain data. The analysis type is incorporated into the AML Platform’s Proximity Path algorithms, allowing for the scrutiny of cross-blockchain flows – no matter how many times inter-blockchain bridges have been crossed. Entity DD allows for easy and fast checking of the risks associated with a specific entity. Coinfirm is perpetually e

Hy Stor Energy Becomes First North American Company to Commit to Global Green Hydrogen Standard10.8.2022 16:21:00 CEST | Press release

Hy Stor Energy LP (Hy Stor Energy), a company pioneering renewably produced green hydrogen and energy storage at scale in Mississippi, announced today it has partnered with the Green Hydrogen Organisation (GH2) to become the first pledge member in North America to advocate for the GH2 Green Hydrogen Standard across the continent and worldwide. By committing to this standard, which is the first of its kind globally, Hy Stor Energy will produce hydrogen with 100% or near 100% renewable energy with close to zero greenhouse gas emissions for its highly anticipated Mississippi Clean Hydrogen Hub and all future projects. “The GH2 Standard provides certainty and transparency to investors and other stakeholders that green hydrogen is exactly that: hydrogen made with renewable electricity which conforms to the highest standards on emissions, ESG and the sustainable development goals,” said Malcolm Turnbull, chairman of GH2. “We are thrilled that Hy Stor Energy has pledged to advocate our standa

Forescout Announces the Appointment of Rik Ferguson to VP of Security Intelligence10.8.2022 15:00:00 CEST | Press release

Forescout Technologies, the leader in automated cybersecurity, today announced the appointment of Rik Ferguson as VP of Security Intelligence. With a career spanning more than 25 years, including 15 years as VP of Threat Research at Trend Micro, Rik is a stalwart of the cybersecurity world. Rik is a researcher, storyteller, and futurist, helping governments, law enforcement, businesses and individuals understand the complexities of technology and its intersection with cybercrime. He has taken deep dives into the cybercriminal underground and helped the wider world understand the threats of today and explored how those threats will change over time. Rik is a founding Special Advisor to Europol’s European Cyber Crime Centre (EC3), a multi-award-winning security professional recognized for his contribution to IT, a Fellow of the Royal Society of Arts, a board advisor to start-ups, and a world-renowned speaker. “I am very excited to be joining Forescout at this point in its growth and jour

In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.

Visit our pressroom