LG Chem Life Sciences and TransThera Biosciences Announce License Agreement for Potential Treatment of NASH and Other Chronic Inflammatory Conditions
LG Chem Life Sciences (“LG Chem”), a division of LG Chem, and TransThera Biosciences Co. Ltd. (“TransThera”), a clinical-stage biotechnology company based in Nanjing, China, announced today that LG Chem has entered an exclusive license agreement with TransThera, for the development and commercialization of TransThera’s TT-01025, a highly selective oral small molecule inhibitor of Semicarbazide-Sensitive Amine Oxidase/Vascular Adhesion Protein-1 (SSAO/VAP-1) that has shown promising efficacy in pre-clinical investigation in non-alcoholic steatohepatitis (NASH). TT-01025 is expected to enter Phase I trial in early 2021 in the US.
This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20200817005331/en/
NASH is a chronic and progressive liver disease characterized by fat accumulation and inflammation in the liver, which can lead to fibrosis and impaired liver function. The disease can be silent for a long period of time, but once it accelerates, severe damage and liver cirrhosis can occur, which can significantly impact liver function or can even result in liver failure or liver cancer. There are as yet no globally approved drugs for the indication. The inhibition of SSAO/VAP-1 blocks oxidative conversion and leucocyte transmigration during inflammation processes and exhibits therapeutic potential across a range of chronic inflammatory conditions, including NASH.
Under the terms of the agreement, LG Chem will obtain exclusive worldwide rights, except Greater China region and Japan, to develop and commercialize TT-01025. TransThera will receive upfront payment as well as development and sales milestone payments, totaling up to $350M, plus tiered royalties on the annual net sales. LG Chem will be responsible for the further development, manufacturing and commercialization of TT-01025.
“Leveraging TransThera’s expertise in drug discovery and LG Chem Life Science’s capability in drug development, we are excited to expand our portfolio in NASH and other metabolic disorders,” said Dr. Jeewoong Son, President of LG Chem Life Sciences. “TT-01025 has a mechanism of action potentially synergistic with those in our own pipeline, making a perfect fit for our strategy to tackle the complex pathophysiology of NASH.”
Dr. Frank Wu, Chairman and CEO of TransThera, commented, “Open innovation is an important part of TransThera’s R&D strategy. We are very excited to collaborate with LG Chem, with its strong and broad expertise and capabilities, to expedite the global development of TT-01025. TT-01025 is a novel, highly differentiated VAP-1 inhibitor, with attributes of minimum CNS exposure and high selectivity, rendering its low risk of drug interactions. We look forward to working with LG Chem to deliver a potential innovative drug for the treatment of NASH patients.”
About LG Chem Life Sciences
LG Chem Life Sciences is a business division within LG Chem, engaged in the development, manufacturing, as well as commercializing pharmaceutical products globally. LG Chem Life Sciences seeks to expand and make global presence by focusing on key core therapeutic areas of Immunology, Oncology, and Metabolic Diseases (specifically, diabetes and related metabolic diseases). To achieve such, its strategy is to actively pursue global collaboration encompassing from asset-centric to strategic investment and collaboration.
About TransThera Biosciences
TransThera Biosciences is a clinical-stage biotechnology company dedicated to developing innovative therapeutics to target diseases with major unmet medical needs via internal research platform and open innovation. TransThera's current portfolio covers therapeutic areas such as oncology, cardiovascular, and inflammatory diseases. For more information, please visit www.transtherabio.com.
LG Chem Media:
Mr. Junam Kim
Ms. Songxi Cui
About Business Wire
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
H2O.ai Launches H2O AI Hybrid Cloud26.1.2021 17:19:00 CET | Press release
H2O.ai announces H2O AI Hybrid Cloud, an end-to-end AI platform that enables organizations to build rapidly, share, and use AI models and applications. An innovative new platform, H2O AI Hybrid Cloud, empowers anyone to innovate and use AI to make better forecasts, streamline operations, reduce risk, and personalize customer experiences. It contains capabilities and automation across the entire data science lifecycle, including connecting to and preparing data, building and explaining models, deploying and operating models, and building and sharing AI applications. “AI is central to AT&T’s mission to deliver wireless, broadband, and software-based video to our customers. We’ve deployed hundreds of AI models to support those products and services, such as to protect our customers by scoring transactions in real-time for the likelihood of fraud. Collaborating with H2O around their open source tools including H2O Wave and H2O AI Hybrid Cloud will let us expand those capabilities across AT
ISACA Releases New Report on Privacy Trends, Obstacles and Predictions Ahead of Data Privacy Day26.1.2021 17:16:00 CET | Press release
As Data Privacy Day approaches this week, ISACA has released a new survey report, Privacy in Practice 2021: Data Privacy Trends, Forecasts and Challenges, exploring past and future trends in privacy by design, privacy obstacles and privacy workforce. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20210126005846/en/ The current privacy landscape is rife with low investment, lack of high-level prioritization and lack of skilled privacy professionals that leave organizations open to penalties and loss of reputation. ISACA, a global professional association and learning organization, surveyed more than 1,800 IT audit, risk, security and privacy professionals on privacy workforce trends and skills gaps, privacy programs, and the regulations and frameworks that guide privacy programs. (Graphic: Business Wire) Privacy by Design Enterprises that report they always use privacy by design are more likely to be driven by a combination of
Xsolla Launches New Mobile Game Commerce Solution to Help Developers Expand Their Mobile Business26.1.2021 16:01:00 CET | Press release
Xsolla, the video game commerce company powered by Transaction Engine and Business Engine to help developers and publishers market, sell, connect and optimize their games globally, today launched its Mobile Game Commerce solution designed to level up and manage mobile games beyond the app stores. Xsolla’s new innovative Mobile Game Commerce solution enables developers to streamline user acquisition, create better ways for players to discover games, simplify the online game commerce experience, build an online player community, expand their global footprint and increase future transaction revenue. Mobile Game Commerce gives developers the tools to successfully operate PC and online versions of their mobile games, and create top-up experiences for players to add virtual currencies to their accounts: Expand onto PC and Online to unlock additional distribution, acquisition and in-game monetization channels for new and existing players. Communicate, better serve and share new offerings with
Andersen Global Expands Coverage in South Africa26.1.2021 15:30:00 CET | Press release
Andersen Global enhances its presence in South Africa through a Collaboration Agreement with full-service accounting and tax consulting firm SAB&T Business Consulting (SAB&T), expanding the organization’s coverage to nine additional cities in the country: Centurion, Bloemfontein, Cape Town, Durban, Kimberley, Nelspruit, Polokwane, Port Elizabeth and Rustenburg. Founded in 1994, SAB&T’s team of professionals serves individuals, SMEs and multinationals in various industries including agriculture, education, entertainment, hospitality, manufacturing, retail and technology. “Our firm has developed strong relationships with our clients by providing best-in-class solutions and maintaining the highest standards of professional conduct and expertise since the birth of South Africa’s democracy in 1994,” Chief Operating Officer Fazel Sulaman said. “Our goal is to remain a leading firm by continuing to meet and exceed clients’ expectations. We look forward to working with Andersen Global’s member
Moody’s Analytics CECL Solutions Complete 2020 SOC 1 ® Examinations26.1.2021 15:00:00 CET | Press release
Moody’s Analytics today announced that the ImpairmentStudio™, RiskCalc™, and CMM™ platforms have completed System and Organization Controls (SOC 1) Type 2 examinations under the attestation standards established by the American Institute of Certified Public Accountants. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20210126005350/en/ The SOC 1 report examination encompasses policies, operating procedures, and controls related to financial reporting of user entities by an independent auditor, to objectively validate that the service organization meets its declared control objectives. Banks, credit unions, and insurance companies use our ImpairmentStudio solution to automate allowance calculations, analysis, reporting, and workflow. This award-winning solution combines our credit risk data, best-in-class analytics, and impairment accounting expertise, and has been celebrated for its completeness and broad CECL automation capabi
Brightcove Receives Two Technology and Engineering Emmy ® Awards26.1.2021 15:00:00 CET | Press release
Brightcove Inc. (NASDAQ: BCOV), the global leader in video for business, today announced it is the recipient of two Technology and Engineering Emmy® Awards, awarded by the National Academy of Television Arts & Sciences (NATAS) for excellence in engineering innovation. The recent accolades further solidify Brightcove’s leadership within the industry, most notably as one of the only online video platforms to be recognized for its distinguished video services. Brightcove’s Context Aware Encoding technology was recognized for excellence and engineering creativity in the Development of Perceptual Metrics for Video Encoding Optimization category. The technology enables customers to distribute videos encoded at high visual quality while minimizing network bandwidth and storage costs. Additionally, Brightcove’s Zencoder and Video Cloud products were acknowledged in the Development of Massive Processing Optimized Compression Technologies category. The award distinguishes Brightcove's innovation
PROFIL ® Launches New Website26.1.2021 15:00:00 CET | Press release
PROFIL®, a PennEngineering® company and leading global manufacturer of mechanically attached fasteners for the automotive market, has announced the launch of a new website, www.profil-global.com. The new website, available in English and German, provides visitors with an enhanced user experience that makes it easy to learn about PROFIL® products, installation methods, and application usage. In addition to its highly intuitive and modern site design, new content features include: Interactive Search – users can search for and filter product information by a variety of features including product type, size, material, application, and fastening method. Cost Calculator – new cost calculator tool determines the potential cost savings gained by using PROFIL® In-Die Mechanically Attached Fasteners (MAF) compared to weld fasteners. Interactive Application Overview – through an animated and interactive vehicle diagram, users can see exactly how and where PROFIL® fasteners are used by application
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.Visit our pressroom