NASDAQ OMX

Novavax' Preclinical Influenza Nanoparticle Study Published in Vaccine

Dela

Novel vaccine candidate, NanoFlu(TM), outperforms market-leading Fluzone® High Dose based on antibody titers and neutralization of recent and historic influenza viruses in a preclinical study

GAITHERSBURG, Md., Aug.  23, 2017  (GLOBE NEWSWIRE) -- Novavax, Inc., (Nasdaq:NVAX) today announced that data from a preclinical study of its nanoparticle influenza vaccine candidate with its proprietary Matrix-M(TM) adjuvant (NanoFlu(TM)) have been published in the journal Vaccine. Novavax is developing NanoFlu to protect older adults from seasonal influenza.

The manuscript describes the formulation of Novavax' novel seasonal influenza vaccine candidate, NanoFlu, based on the 2017-2018 World Health Organization (WHO) recommended influenza strains. The study, conducted in ferrets, found that NanoFlu induced hemagglutination-inhibition (HAI) and microneutralizing (MN) antibodies against a broad range of influenza subtypes. In a head-to-head comparison against standard-dose and high-dose (HD) inactivated influenza vaccines in ferrets, NanoFlu elicited higher HAI and MN antibody responses exceeding those induced by the high-dose vaccine against recent (homologous) A(H3N2) by 7-fold, A(H1N1) by 26-fold, and B strain viruses by 2-fold. Additionally, NanoFlu induced superior protection in a ferret challenge model against a homologous and a 10-year old drifted influenza strain spanning over a decade.

"These data suggest that NanoFlu has the potential to elicit a broader, more robust immune response, resulting in greater protection than the market-leading licensed influenza vaccine in older adults, Sanofi's Fluzone® High-Dose. NanoFlu outperformed standard dose Fluzone and Fluzone HD in HAI assays, an established surrogate marker of protection," said Gregory Glenn, M.D., President, Research and Development. "Further, these data suggest NanoFlu has the potential to address the problem of annual strain mismatch due to its ability to induce highly neutralizing antibodies against a broad range of influenza strains. These data show that NanoFlu provides improved protective responses to both the current recommended influenza strains as well as drifted strains."

"Novavax has over a decade of experience in developing both seasonal and pandemic influenza vaccine candidates. Based on the superior attributes of our nanoparticle based vaccine candidates, we transitioned our influenza development activities to our nanoparticle vaccine platform," said Stanley C. Erck, President and CEO. "The data in this publication further validate our nanoparticle vaccine platform and provide a strong rationale for advancing NanoFlu into a Phase 1/2 clinical trial. Our goal is to deliver a superior, differentiated vaccine to the greater than $3 billion global seasonal influenza commercial market1."

Copies of this paper are available to credentialed journalists upon request; please contact Elsevier's Newsroom at newsroom@elsevier.com or +31 20 485 2492. "Novel hemagglutinin nanoparticle influenza vaccine with Matrix-M(TM) adjuvant induces hemagglutination inhibition, neutralizing, and protective responses in ferrets against homologous and drifted A(H3N2) subtypes," by Gale Smith, Ph.D., Ye Liu, Ph.D., David Flyer, Ph.D., Michael J. Massare, Ph.D., Bin Zhou, Ph.D., Nita Patel, Ph.D., Larry Ellingsworth, Ph.D., Maggie Lewis, Ph.D., James F. Cummings, M.D., Greg Glenn, M.D., DOI: http://dx.doi.org/10.1016/j.vaccine.2017.08.021 appears in Vaccine, published by Elsevier and is available online at www.elsevier.com/locate/vaccine.

About Vaccine
Vaccine is the pre-eminent journal for those interested in vaccines and vaccination. It is the official journal of The Edward Jenner Society and The Japanese Society for Vaccinology and is published by Elsevier, www.elsevier.com/locate/vaccine.

About Novavax

Novavax, Inc. (Nasdaq:NVAX) is a clinical-stage biotechnology company committed to delivering novel products to prevent a broad range of infectious diseases. Our recombinant nanoparticles and Matrix-M(TM) adjuvant technology are the foundation for groundbreaking innovation that improves global health through safe and effective vaccines. Additional information about Novavax is available on the Company's website, novavax.com.

References
1. PharmaPoint Seasonal Influenza Vaccines Global Drug Forecast and Market Analysis to 2025, October 2016

Forward-Looking Statements

Statements herein relating to the future of Novavax and the ongoing development of its vaccine and adjuvant products are forward-looking statements. Novavax cautions that these forward looking statements are subject to numerous risks and uncertainties, which could cause actual results to differ materially from those expressed or implied by such statements. These risks and uncertainties include those identified under the heading "Risk Factors" in the Novavax Annual Report on Form 10-K for the year ended December 31, 2016 and the Report on Form 10-Q for the period ended June 30, 2017, both as filed with the Securities and Exchange Commission (SEC). We caution investors not to place considerable reliance on the forward-looking statements contained in this press release. You are encouraged to read our filings with the SEC, available at sec.gov, for a discussion of these and other risks and uncertainties. The forward-looking statements in this press release speak only as of the date of this document, and we undertake no obligation to update or revise any of the statements. Our business is subject to substantial risks and uncertainties, including those referenced above. Investors, potential investors, and others should give careful consideration to these risks and uncertainties.

Contact:
Investor Relations
Novavax, Inc.
Andrea N. Flynn, Ph.D.
Director, Investor Relations
ir@novavax.com
240-268-2000

Westwicke Partners
John Woolford
john.woolford@westwicke.com
443-213-0506

Media
Russo Partners, LLC
David Schull
Maggie Beller
david.schull@russopartnersllc.com
maggie.beller@russopartnersllc.com
212-845-4271




This announcement is distributed by Nasdaq Corporate Solutions on behalf of Nasdaq Corporate Solutions clients.
The issuer of this announcement warrants that they are solely responsible for the content, accuracy and originality of the information contained therein.
Source: Novavax, Inc. via Globenewswire

Om

NASDAQ OMX
NASDAQ OMX



Följ NASDAQ OMX

Skriv in din e-postadress så får du ett mejl när vi har något nytt att berätta.

Senaste pressmeddelandena från NASDAQ OMX

NTT Security Launches Security Services for Industrial Control Systems20.9.2017 10:00Pressmeddelande

Cyber-defense for critical infrastructure including factories, plants, utilities & hospitals TOKYO, Sept. 20, 2017 (GLOBE NEWSWIRE) -- NTT Security Corporation (Head Office: Chiyoda-Ku, Tokyo; CEO: Jun Sawada), the specialized security company of NTT Group, has launched "IT/OT Integrated Security Services". The new services will be taken to market globally through the NTT Group companies, Dimension Data, NTT Communications and NTT DATA, forming part of its suite of integrated services to enable successful digital transformation initiatives for its clients. Companies are increasingly working towards IT/OT (Operational Technology) alignment. OT systems, when connected to the internet, streamline business operations by advanced supply chain management, realization of mass customization and improvement of customer experience as well as find new intelligence employing IoT (the Internet of Things) and Big Data analytics. As a result, IT/OT convergence is ex

NTT Security lanserar säkerhetstjänster för industriella styrsystem20.9.2017 10:00Pressmeddelande

Cyberförsvar för kritisk infrastruktur, bland annat fabriker, anläggningar, försörjningssystem och sjukhus STOCKHOLM, 20 september 2017 (GLOBE NEWSWIRE) -- NTT Security Corporation, (huvudkontor: Chiyoda-Ku, Tokyo; CEO: Jun Sawada) det specialiserade säkerhetsföretaget inom NTT Group, lanserar IT/OT-integrerade säkerhetstjänster. De nya tjänsterna kommer att lanseras på den globala marknaden genom företag som ingår i NTT Group, nämligen Dimension Data, NTT Communications och NTT DATA. De kommer att ingå i ett erbjudande med integrerade tjänster som möjliggör en framgångsrik digital omvandling för företagets kunder. Företag arbetar alltmer med att sammanlänka IT och OT-system (IT-system för processtyrning) som gör att företagsverksamheter kan ansluts till internet. Detta sker genom en avancerad hantering av leveranskedjan, realisering av masskundanpassning och en förbättrad kundupplevelse. De införskaffar även ny information och underrättelser genom tillämpning av IoT (sak

Zumio(TM) Now Available in Europe20.9.2017 08:00Pressmeddelande

Exclusive Partnership Agreement Signed with Eropartner Distribution Ottawa, Sept. 20, 2017 (GLOBE NEWSWIRE) -- Zumio Inc. proudly announces it has partnered exclusively with Eropartner Distribution for distribution across all 28 EU member countries. Winner of the  Best New Product at ADULTEX 2017, Zumio is the world's only clitoral stimulator based on the proven circular fingertip motion. Zumio's patented SpiroTIP(TM) and motor clutch drive system allows users to dynamically go from high speed and intensity down to a low speed and intensity, without having to touch a control, to instinctively and more naturally, adjust the stimulation to suit their needs. "Traditional vibrators generate excess energy and shake everything they touch often creating sensory overload and a numbing effect," said Steve Traplin, Chief Revenue Officer at Zumio. " Our non-vibrating technology makes Zumio more comfortable to hold and the small TIP and

Juniper Systems Limited Eyes German Market with InterGeo 2017 Exhibit, Opens New Office in Wels, Austria20.9.2017 04:16Pressmeddelande

BIRMINGHAM, United Kingdom, Sept.  19, 2017  (GLOBE NEWSWIRE) -- Manufacturer of rugged handheld data collectors Juniper Systems Limited aims to expand its footprint in the German marketplace. Coinciding with the opening of its new office in Wels, Austria, the company will exhibit at the geometrics industry trade fair, InterGeo 2017, next week in Berlin, Germany. A photo accompanying this announcement is available at http://www.globenewswire.com/NewsRoom/AttachmentNg/ec8e4e2c-b277-48f9-bce9-4606d17454a5 The Wels location was recently opened to serve German-speaking partners and customers in Austria, Germany, and other Eastern European countries. Juniper Systems will showcase its ultra-rugged solutions for GIS, geomatics and geoinformation applications in Hall 1.1 on Stand C1.010 on 26 - 28 September at InterGeo. 'We're excited to be exhibiting at the InterGeo trade fair, which is now a regular date in our diary', commented Simon Bowe, general manager of Juni

CallidusCloud Unveils Game-Changing Augmented Intelligence Platform for Sales Performance, Execution and Learning Customers19.9.2017 22:35Pressmeddelande

Thunderbridge AI³ Combines the Power of Artificial Intelligence, Application Integration, and Human Insight to Provide Contextual Augmented Intelligence Recommendations throughout the Lead to Money suite DUBLIN, Calif., Sept. 19, 2017 (GLOBE NEWSWIRE) -- Callidus Software Inc. (NASDAQ:CALD), a global leader in cloud-based sales, marketing, learning, and customer experience solutions, unveiled its newest platform, Thunderbridge Augmented Intelligence - or Thunderbridge AI³ - today at CallidusCloud Connections (C3) 2017, its annual user conference. The new solution is comprised of three elements: artificial intelligence, application integration, and human insight. The Thunderbridge Augmented Intelligence platform is a layer of software that applies machine learning techniques to the sales and learning processes to come up with recommended actions for increasing revenue, profit, and sales effectiveness. The role of human insight and behavior is key to Thunderbridge AI

Novavax to Present at the Ladenburg Thalmann 2017 Healthcare Conference19.9.2017 22:05Pressmeddelande

GAITHERSBURG, Md., Sept.  19, 2017  (GLOBE NEWSWIRE) -- Novavax, Inc., (Nasdaq:NVAX) today announced the Company will present at the Ladenburg Thalmann 2017 Healthcare Conference. Presentation details are as follows: Date: Tuesday, September 26, 2017 Time: 11:00 - 11:25 am ET Location: Track 5, Montmartre, Sofitel Hotel, New York City Live webcast: www.novavax.com, "Investors"/"Events" A replay of the presentation will also be accessible under the "Investors/Events" section of the Novavax website at novavax.com. About Novavax Novavax, Inc. (Nasdaq:NVAX) is a clinical-stage biotechnology company committed to delivering novel products to prevent a broad range of infectious diseases. Our recombinant nanoparticles and Matrix-M(TM) adjuvant technology are the foundation for groundbreaking innovation that improves global health through safe and effective vaccines. Additional inf

I vårt pressrum kan du läsa de senaste pressmeddelandena, få tillgång till pressmaterial och hitta kontaktinformation.

Besök vårt pressrum