PHC Unveils Prototype of LiCellGrow, New Cell Expansion System to Support Development of Cell and Gene Therapy Products Manufacturing Process
PHC Corporation Biomedical Division (Headquarters: Chiyoda-ku, Tokyo; President: Nobuaki Nakamura, hereinafter referred to as "Biomedical Division") will showcase a prototype of its new cell expansion system LiCellGrow at the ISCT (International Society for Cell & Gene Therapy) Europe 2024 Regional Meeting held in Gothenburg, Sweden on September 4-6. LiCellGrow, currently under development, is designed to allow pharmaceutical companies to visualize continuous metabolic changes in cells in real-time and adjust the cell culture automatically to optimize conditions for cell growth. The system seeks to expand availability of cell and gene therapy (CGT) products by accelerating the manufacturing of specific cells needed for these therapies.
This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20240830467786/en/
(Graphic: Business Wire)
CGT, in which a patient’s cells are removed, modified, and reintroduced to the body to fight disease, has emerged as a promising therapeutic field for difficult-to-treat conditions such as cancers and hematologic disorders. Since the patient’s own cells are used as raw materials, it is essential to maintain stable cell quality when producing new cells, to counteract natural variations in cell characteristics and ensure consistency throughout the therapy manufacturing process. The current method of evaluating cell quality by sampling the final product may lower both manufacturing efficiency and yield, increasing production cost.
LiCellGrow seeks to enable more efficient and stable manufacture of high-quality CGT products by enabling researchers to monitor and control the cell culture environment in real time, optimizing cell quality while minimizing interruption to the therapy manufacturing process.
The system under development uses proprietary In-Line monitoring technology, which continuously measures cell metabolites in the culture medium without the need for repeated sampling by immersing sensors in the medium at all times. LiCellGrow then continuously and accurately measures concentrations of two critical indicators of cell metabolism, glucose and lactate, to offer a visualization of actual changes in the culture environment and cell status. Based on real-time measurement data, the system then automatically exchanges the culture medium to maintain the culture environment in an optimal state. This technology is designed to improve and homogenize cell quality while increasing cell culture efficiency and reducing costs through loss reduction. The system will also feature easy-to-install single-use culture bags with In-Line sensors, enabling closed-system cell culturing to maintain a sterile environment, and can be installed in existing CO2 incubators, enabling researchers to conduct studies using their preferred equipment.
LiCellGrow is an example of synergy between the Biomedical Division and IVD Division (hereinafter referred to as “IVD”) of PHC Corporation. The In-Line monitoring technology featured in this cell expansion system is newly developed proprietary technology building on the core technology of blood glucose sensor, the main product developed by IVD. By combining this sensor technology from IVD with advanced cell culture environment control technology from the Biomedical Division, PHC seeks to offer researchers and pharmaceutical companies greater value.
The Biomedical Division plans to launch LiCellGrow to support the development of manufacturing processes for CGT products globally in the short term, and aims to accelerate development of this system to ultimately support commercialized production of CGT products.
LiCellGrow builds on the Biomedical Division’s 20-year history of pioneering solutions in the field of cell therapy, including the Cell Processing Center*1 in 2000 and the Cell Processing Isolator *2 in 2007. Moving forward, we will continue to accelerate the creation of innovative solutions addressing QCD (Quality, Cost, Delivery) challenges in the therapeutic manufacturing process for early adoption of CGT, aiming to contribute to advancing modalities (therapy methods.)
ISCT Europe 2024 | ||
Event period: | Sept. 4 to 6, 2024 | |
Location: | Gothenburg, Sweden | |
Venue: | Swedish Exhibition & Congress Center | |
(PHC Europe B.V. Booth No. F03.12) | ||
Website: | Home - ISCT EU 2024 (isctglobal.org) |
*1 Strictly controlled cell processing facilities for aseptic processing of cell culture, processing, among others.
*2 Device that combines a closed space sterilized with hydrogen peroxide inside the isolator, detachable culture modules, centrifuge modules, and other components, allowing a series of cell processing steps to be performed while retaining a sterile environment.
About the Biomedical Division of PHC Corporation
Established in 1969, PHC Corporation is a Japanese subsidiary of PHC Holdings Corporation (TOKYO:6523), a global healthcare company that develops, manufactures, sells, and services solutions across diabetes management, healthcare solutions, life sciences and diagnostics. The Biomedical Division supports the life sciences industry helping researchers and healthcare providers in around 110 countries and regions through its laboratory and equipment and services including CO2 incubators and ultra-low temperature freezers.
www.phchd.com/global/phc
About PHC Holdings Corporation
PHC Holdings Corporation (TOKYO:6523) is a global healthcare company with a mission of contributing to the health of society through healthcare solutions that have a positive impact and improve the lives of people. Its subsidiaries include PHC Corporation, Ascensia Diabetes Care Holdings AG, Epredia Holdings Ltd., LSI Medience Corporation, Wemex Corporation, and Mediford Corporation. Together, these companies develop, manufacture, sell and service solutions across diabetes management, healthcare solutions, diagnostics and life sciences. The consolidated net sales in FY2023 were JPY 353.9 billion with global distribution of products and services in more than 125 countries and regions. PHC Group is a collective term referring to PHC Holdings Corporation and its subsidiaries.
www.phchd.com
View source version on businesswire.com: https://www.businesswire.com/news/home/20240830467786/en/
Contacts
Contact for product and service:
Masayo Okada
Marketing Department, Biomedical Division
PHC Corporation
Email: masayo.okada@phchd.com
Arthur Goudena
Marketing Manager
PHC Europe B.V.
Tel: +31-76-5433-833
Email: arthur.goudena@eu.phchd.com
Contact for IR and media:
Hiroko Arai
Investor Relations & Corporate Communications Department
PHC Holdings Corporation
Tel: +81-3-6778-5311
Email: phc_pr@gg.phchd.com
(c) 2024 Business Wire, Inc., All rights reserved.
Business Wire, a Berkshire Hathaway company, is the global leader in multiplatform press release distribution.
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
Wipro Appoints Srikumar Rao as Global Head of Its Engineering Edge Business Line30.8.2024 16:20:00 CEST | Press release
Wipro Limited (NYSE: WIT, BSE: 507685, NSE: WIPRO), a leading technology services and consulting company, today announced the appointment of Srikumar Rao as Global Head of its Engineering Edge Business Line, effective from October 5, 2024. Srikumar succeeds Harmeet Chauhan, who is stepping down to pursue opportunities outside the organization. Srikumar will report to Srini Pallia. Srikumar has been with Wipro for 26 years and has grown with the organization, serving in various leadership roles. He was most recently the Chief Operating Officer (COO) of Wipro Engineering Edge (WEE) and Global Practice Head of Embedded Systems. His work has spanned several markets, selling and delivering specialized Engineering, Research, and Development (ER&D) services to Software & Internet, Semiconductor, Automotive, Manufacturing, and Communications clients. In his new role, Srikumar will continue to scale and strengthen Wipro’s engineering prowess. He will also be responsible for defining the vision
Alnylam Presents Detailed Results from the Positive HELIOS-B Phase 3 Study of Vutrisiran▼ in Patients with ATTR Amyloidosis with Cardiomyopathy at the European Society of Cardiology Congress30.8.2024 12:00:00 CEST | Press release
Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), the leading RNAi therapeutics company, today announced detailed results from the HELIOS-B Phase 3 study of vutrisiran, an investigational RNAi therapeutic in development for the treatment of ATTR amyloidosis with cardiomyopathy (ATTR-CM). The data were presented today in a Hot Line session at the European Society of Cardiology (ESC) Congress 2024, taking place August 30-September 2 in London, United Kingdom. Results from the HELIOS-B study were also simultaneously published in TheNew England Journal of Medicine. As previously reported, the HELIOS-B study met all 10 of its primary and secondary endpoints, across both the overall and monotherapy populations, with statistical significance. Enrolled patients were predominantly New York Heart Association (NYHA) Class I or II with wild-type disease and had been diagnosed by non-invasive methods, with substantial concurrent treatment with available standard of care treatments such as tafamidis and
Kaneka Completes Construction of Medical Device Plant in Hokkaido30.8.2024 07:34:00 CEST | Press release
Kaneka Corporation (Headquarters: Minato-ku, Tokyo; President: Kazuhiko Fujii) (TOKYO:4118) opened its Tomatoh Manufacturing Site in the Tomakomai Tobu Area of Hokkaido for the purpose of portfolio transformation and business expansion and held the opening ceremony on August 26. The Tomatoh Manufacturing Site is the seventh domestic business location*1 for the company and the first new one in 54 years. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20240829240050/en/ Tomatoh Manufacturing Site (Photo: Business Wire) The medical device plant*2 completed at Tomatoh Manufacturing Site will produce adsorption type blood purification devices "Rheocarna™" and adsorption type plasma purification devices "Liposorber™". The number of patients with arteriosclerosis obliterans (ASO)*3, which these medical devices are intended to treat, is on the rise worldwide, along with increases in diabetes, chronic renal failure, and other conditions
FPT Software Partners with Blue Yonder to Transform Supply Chain Management Across Southeast Asia30.8.2024 06:35:00 CEST | Press release
Global IT company FPT Software announced a partnership with Blue Yonder, the world leader in digital supply chain transformations, to deliver end-to-end supply chain management solutions tailored to the needs of businesses across various industries in Southeast Asia. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20240829950683/en/ The partnership signing ceremony took place in Hanoi, Vietnam with Blue Yonder Asia Pacific Alliances Director Lakshmikanth Sundararajan, Blue Yonder Southeast Asia Senior Sales Director Anand Kumar, and FPT Software SEVP Nguyen Khai Hoan. (Photo: Business Wire) The partnership targets six key markets, including Singapore, Malaysia, Thailand, Indonesia, Vietnam, and the Philippines. Leveraging Blue Yonder’s world-class supply chain solutions and FPT Software’s extensive reach and implementation experience in these markets, the partnership is expected to deliver rapid, customized supply chain managem
Rimini Street Honored as Best Workplaces™ for Millennials 2024 India and a Great Place to Work® Australia29.8.2024 22:30:00 CEST | Press release
Rimini Street, Inc. (Nasdaq: RMNI), a global provider of end-to-end enterprise software support, products and services, the leading third-party support provider for Oracle and SAP software, and an AWS partner, proudly announces that Rimini Street India has been awarded as one of the Best Workplaces™ for Millennials, and Rimini Street Australia has been honored as a Great Place to Work® 2024. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20240829270348/en/ Rimini Street Honored as Best Workplaces™ for Millennials 2024 India and a Great Place to Work® Australia (Photo: Business Wire) Great Place to Work® is the global authority on workplace culture, employee experience, and leadership behaviors proven to deliver market-leading revenue, employee retention, and increased innovation. Best Workplaces™ awards are granted upon review of the detailed Culture Brief™ benchmarked against industry and regional peers. “Rimini Street contin
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.
Visit our pressroom