Business Wire

Agendia Presents Data at ASCO 2022 Pointing to New Signature ImPrint Immunotherapy Prediction and Expansion of Proprietary Genomic Tests’ Utility to Identify Patients Who Will Benefit Most from Specific Treatments

Share

Agendia, Inc., a commercial-stage company focused on improving outcomes for breast cancer patients worldwide by providing physicians and patients with next-generation diagnostic and information solutions to inform optimized treatment decision-making, today announced it will share findings in a poster discussion debuting initial data from its ImPrint test, a 53-gene signature in development, at the American Society of Clinical Oncology Annual Meeting (ASCO) 2022.

The poster discussion, titled The ImPrint immune signature identifies high risk early breast cancer patients who may benefit from PD1 checkpoint inhibition in I-SPY2 [Kuilman, M., et al.],draws from the neoadjuvant biomarker-rich I-SPY2 trial, which established a new benchmark for the efficacy of Phase 2 clinical trials and is widely regarded as the pioneer of the platform trial. In this study, whole transcriptome data collected by Agendia was assessed from patients who had high risk early breast cancer who received immunotherapy (IO). The goal was to migrate the I-SPY2 findings into a robust clinical-grade signature – a biomarker that had not previously existed in early stage breast cancer – to predict sensitivity to IO drugs that target PD-1/PDL-1, a cell pathway that, when overexpressed, allows many breast tumors to escape destruction by the immune system.

Importantly, results showed that in the development phase, the gene-expression biomarker ImPrint met this task and had the potential to predict pathologic complete response (pCR) to PD-1/PDL-1 checkpoint inhibitors with high sensitivity and specificity, especially in ER+ breast cancer which represents a large population of women who may benefit.

“We are incredibly encouraged by the data we are sharing with regard to the ImPrint Test, which is currently in development,” said Annuska Glas, Senior Vice President Research and Development and Innovation at Agendia. “ImPrint appears very effective in identifying a subset of HR+HER2- patients who could benefit from IO. We are also interested in the signature’s ability to identify tumors with an immune active phenotype denoted by the enrichment of several immune-related pathways. This kind of information is not currently available to a broad range of patients with breast cancer, and while we are in the research use only stage, we look forward to continuing validation to ensure ImPrint is in physicians’ hands as soon as possible.”

The effect of these findings on patients is potentially significant, ultimately having the potential to impact outcomes. The data shared at ASCO 2022 point to the RUO ImPrint Test’s ability to find those who will benefit from a PD-1/PDL-1 treatment as initial therapy, regardless of receptor subtype, providing the information needed to define more specific treatment planning soon after diagnosis.

“There has been a substantial increase of novel IO drugs in many types of diseases, which are astoundingly effective in some cases but not a panacea for all. This had led to the urgent need for biomarkers to identify which patients may benefit from them,” said Midas M. Kuilman, Research and Development, Agendia NV, Amsterdam and first author on the poster. “We see this signature as addressing an unmet need as various predictive biomarkers have been developed, but none have consistently predicted efficacy. Here, we see that ImPrint appears to predict with high sensitivity and specificity in both discovery and validation sets – it’s an incredibly promising set of data and we look forward to validating it in the I-SPY 2.2 trial.”

Redefining Breast Cancer Care in Post-Neoadjuvant Settings

Another poster, presented by Agendia in partnership with investigators from Cedars-Sinai Medical Center, Los Angeles, looks at matched tumors pre- and post-neoadjuvant chemotherapy analyzed by both MammaPrint® and BluePrint® to report differential gene expression and pathway analyses in the tumors that may help distinguish different responses. The poster, titled Identification of transcriptional changes with MammaPrint and BluePrint in early-stage breast cancer after neoadjuvant chemotherapy [Chung, A., et al.],found a more robust transcriptional change in tumors that remain MammaPrint High Risk between pre- and post-neoadjuvant chemotherapy. While these tumors remained High Risk, they also had many changes in gene expression pre- and post-neoadjuvant chemotherapy, unlocking clues to resistance and inspiring further research.

The study also found that tumors which changed from MammaPrint High Risk to MammaPrint Low Risk post-therapy had an activated immune response that may be a biomarker for therapy response and improved outcomes based on it.

Taken together, these posters represent Agendia’s continuous dedication to producing and evolving products that lead to insights across the breast cancer care continuum, from initial diagnosis to tailored treatment guidance.

In addition, Agendia will be presenting six posters and a second poster discussion centered on its revolutionary FLEX Trial, which is accelerating impactful data generation aimed at redefining cancer care. Its patient-centric design and national network of participating sites is backed by Agendia’s infrastructure, allowing its investigator-initiated sub-studies to produce important results that have the potential to drive science forward.

Agendia will be sharing updates throughout the conference on its Twitter, Facebook and LinkedIn pages.

About Agendia

Agendia is a mission-driven, commercial stage company focused on enabling optimized decision-making by providing physicians with next-generation diagnostic and information solutions that can be used to help improve outcomes for breast cancer patients worldwide. The company currently offers two commercially-available genomic profiling tests that help surgeons, oncologists and pathologists to personalize treatment for women at critical intervention points throughout their patient journey.

MammaPrint® is a 70-gene prognostic test that, along with other clinicopathologic factors, determines a specific patient’s breast cancer recurrence risk. BluePrint® is an 80-gene molecular subtyping test that identifies the underlying biology of an individual breast cancer to provide information about its behavior, long-term prognosis and potential response to systemic therapy. Together, MammaPrint® and BluePrint® provide a holistic view of the biology underlying an individual patient’s breast cancer, enabling physicians to objectively select the best treatment plan.

For more information on Agendia’s assays and ongoing trials, please visit www.agendia.com.

To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.

Contact information

Terri Clevenger
Westwicke/ICR Healthcare PR
Tel: 203.856.4326
Terri.Clevenger@icrinc.com

About Business Wire

Business Wire
Business Wire



Subscribe to releases from Business Wire

Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.

Latest releases from Business Wire

Thales Introduces S3NS in Partnership With Google Cloud and Unveils Its Offering in a First Step Towards the French Trusted Cloud Label30.6.2022 14:20:00 CEST | Press release

Thales announced today the creation of S3NS, a French company designed to offer public and private organizations in France the power of Google Cloud, fully compliant with France's “Trusted Cloud” label, in partnership with Google Cloud. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20220630005160/en/ (Graphic: Thales) The new company, majority owned and controlled by Thales, is under French law and follows the October 2021 partnership announcement between Thales and Google Cloud to jointly develop a locally-compliant Trusted Cloud offering. Thales and Google Cloud are committed to helping companies and public institutions to innovate and accelerate their digital transformation in ways that afford autonomy, compliant sovereignty, and the greatest possible benefits for their customers and users. Meeting the French “Trusted Cloud” S3NS will offer from the second half of 2024 its “trusted cloud” offering that will ultimately comb

ExaGrid Named to First-Ever MES Matters – Key Vendors Serving the Midmarket List30.6.2022 14:00:00 CEST | Press release

ExaGrid®, the industry’s only Tiered Backup Storage solution, today announced that Midsize Enterprise Services (MES), a brand of The Channel Company, has recognized ExaGrid on its 2022 MES Matters- Key Vendors Serving the Midmarket list. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20220630005185/en/ (Graphic: Business Wire) The MES Matters list recognizes vendors that have proven themselves to be forward-thinking technology providers offering solutions that support the growth and innovation of midmarket organizations. MES defines the midmarket as an organization with an annual revenue of $50M-$2B and/or 100-2500 total supported users/seats. Companies were selected due to their go-to-market strategy, how they serve the midmarket, and the strength of their midmarket product portfolios. ExaGrid focuses on the Midmarket to the Large Enterprise and offers the most value to customers who back up 50TB to 100s of PB of data, and ke

Leveraging the power of the cloud, Managed File Transfer helps organizations modernize and deliver value in an always-on world30.6.2022 14:00:00 CEST | Press release

Axway (Euronext: AXW.PA), a leader in API-driven B2B integration and MFT software, is pleased to announce its newest release of Axway Managed File Transfer (MFT), available in both the Microsoft Azure and Amazon Web Services Cloud. As the demand and complexity of data transfers continue to grow in a post-pandemic world, companies need trusted solutions to mitigate the risks of cyber threats, legacy system obsolescence, and a shortage of human resources. “Managing mission-critical dataflows requires a more modern approach,” says Meetesh Patel, General Manager of Managed File Transfer at Axway. “Many of the largest banks, retailers, and auto manufacturers in the world already rely on us to power their operations. With Axway MFT, businesses can control more data at scale with security, resiliency, and speed while empowering their business users and satisfying regulatory and governance requirements.” Businesses are adapting to doing business in an always-on world, and time-trusted solution

Yagi & Co., Ltd. : Textile E-commerce Site Fably Further Improves as a Platform by Launching Services to Handle International Orders30.6.2022 12:00:00 CEST | Press release

Fably (https://www.fably.jp), a textile e-commerce site operated by YAGI & CO., LTD, (TOKYO:7460) (https://www.yaginet.co.jp/en/) aims to create a future of new manufacturing technologies through the use of digital technology to connect people in all fields of the textile industry under the concept of a “professional tool for textile”. In addition to product introductions, the site also features a broad range of other content in order to provide valuable information for experts in textile business. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20220630005055/en/ Main Image (Graphic: Business Wire) Previously, Fably had only handled orders from within Japan, but the site is now able to handle international orders as well. Participating Companies Currently, 33 companies in total offer their products through the site. The varieties of products available have increased in stages over time, from easy-to-use plain and patterned fab

Vita Mojo Raises US$30 Million to Help Restaurant and Hospitality Chains in Europe Tackle the Digital Future30.6.2022 12:00:00 CEST | Press release

Vita Mojo, the European leader in “front-of-house” restaurant software powering digital ordering and the management of smarter, more-efficient kitchen and delivery operations, has raised US$30 million in new financing to refine its product and expand into new markets. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20220630005213/en/ Vita Mojo Co-Founders Nick Popovici (left) and Stefan Catoiu. (Photo: Business Wire) The funding round was led by global technology investment firm Battery Ventures, an investor in a number of U.S.-based restaurant and hospitality-tech companies including Olo* and CrunchTime! Information Systems*. Battery General Partner Morad Elhafed and Principal Zak Ewen will join Vita Mojo’s board. Vita Mojo – which sells to restaurants, pubs, coffee shops, bakeries and fast-casual eateries – counts large chains among its customer base including Nando’s, GAIL’s Bakery, Le Pain Quotidien, LEON, JKS Group and Nea

In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.

Visit our pressroom